Ankle sprain involves injury to a ligament in the ankle. Many people have experienced an ankle sprain at some point in their life, often resulting from falling, tripping or rolling the ankle. People who play sports are often susceptible to ankle sprains.
Shin splint pain will occur on the inside of the lower leg, just beneath the halfway mark of the shin. The pain will often come on after a period of time, and may or may not be so intense as to cause the runner to cease running. In more serious cases, the pain will remain for a period after stopping running.